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Python

How to use Django forms to execute a python file and then make it executable to use it as a desktop app?

I need to write a complex dynamic GUI to get some information from the user and then execute a python file with that.

The the tools available for coding a GUI on python (TKinter, PyQT, etc..) are good for small and simple GUI's. That is why I thought it would be possible to write the GUI on HTML + Bootstrap (using Django for exmple) and then execute the python script.

I am wondering if something like that is possible and if so, how?

Any ideas?

PD. I would like the GUI to run locally instead, more like a desktop app..

Thanks