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In this chapter, the discussion centers on advanced threat detection and defense techniques for web applications, with an emphasis on integrating and benchmarking various security analysis tools. The chapter reviews existing research on static, dynamic, and interactive analysis tools (SAST, DAST, and IAST), proposes a novel methodology for combining these tools to enhance vulnerability detection while reducing false positives, and provides practical insights and rankings based on a comprehensive evaluation using the OWASP Benchmark project.