Can you use filezilla more than once

Certainly! You can connect FileZilla to any server to upload files, or upload multiple times to the same server. In fact, if you upload the same files to the same location a second time, you have the option to write over the existing ones on the server. Therefore, you can update a file on your desktop, upload it via FileZilla, and have it update the server copy.

I definitely recommend reading up on using FileZilla on their wiki.

I use FileZilla to manage the FTP (File Transfer Protocol) of all of my websites, it is the only program I use to upload anything to my webserver, as Austin pointed out if you upload a duplicate file to one that already exists in the same location on your webserver it warns you first and gives you options on how you would like to proceed.

The only thing you have to be careful about - part of a Wordpress site

usually exists inside a MySQL database.

So if you are transferring or updating that particular part of the Wordpress site it will

probably have to be done through phpAdmin interface or whatever

browser-based CPanel your host provider uses.