Remove all default CSS properties from browser.

I'd say that your best bet is to use normalize.css. Some browsers (and even some versions of the same browsers) have some interesting CSS rules that can make a site look different on one than on the other. Normalize.css is used by some big sites including (but not limited to) Twitter.

The idea here is to give the same CSS rules across all versions of all browsers giving you a sort of "blank slate" to work with. This helps ensure that the site you are building looks the same across browsers (and versions of browsers).

You can find normalize.css here. It is, of course, free to use. Down at the bottom of this page you can see more big sites that use it.

Hope this helps!

It sounds like you may be looking for the "Meyer reset", one of the more popular alternatives to normalize.css. It's not better or worse then normalize, just a different approach. Instead of smoothing out the differences, it literally zeros out everything. It leaves you as close to a blank canvas to override with your own styles as possible.

Thanks Jennifer and Seth! Considering either creating a 12 or 16 column grid, which would you advise to be the better option.