Will/can there be a Python course module in which a real world business application is developed?

Our products will get more and more "real world" but will likely never be a cut-and-dried business app because a) that's not all that exciting to build or learn from; and b) there are so many variables in the real world and I don't want to give people a false sense of "this is exactly how you do it".

That said, everything you've been taught has real world applications, most of them exactly as they're used in the courses already. Taking unlimited input and then working on it. Drawing information to the screen either through text layout or ASCII art. Using different collection types to hold onto information more appropriately. Writing custom classes and modules to logically model problems. Manipulating dates and times to reflect real locations on Earth. Using pdb to find problems in your code. Creating logs from your applications. Coding to the PEP8 standard. Using Flask to accept arguments and send responses. And on and on and on.

So, yes, we may not be building the next great bit of accounting software or the next web start up. We are, however, building the foundation and tools that every piece of software comes from.

Perhaps for those types of applications we'd first need a course on databases in general

there is the Database Foundations course if you are interested.

I remember when Treehouse first posted the job listing for a Python developer, and it specifically requested Django experience. I'd say a course on Django is in the making and should come out relatively soon, especially now that we've had a Flask one. :)

Theres a lot of good resources for learning through application.

A good one I found recently was Real Python. I think a lot of what you're asking is covered in their courses and tutorials.